Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction
Identifieur interne : 002856 ( Main/Exploration ); précédent : 002855; suivant : 002857Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction
Auteurs : Ichiro Kanazawa ; Shin Kwak ; Hidenao Sasaki ; Osamu Muramoto ; Toshio Mizutani ; Akira Hori ; Nobuyuki NukinaSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1987.
Abstract
γ-Aminobutyric acid (GABA), substance P and dopamine concentrations and choline acetyltransferase (ChAT) activity were measured in post-mortem cerebro-cortical and basal ganglial areas of 14 controls and 4 patients with pathologically verified Pick's disease (1 classic case and 3 cases of the generalized form). GABA and substance P levels in the substantia nigra and the globus pallidus were generally decreased, corresponding to the moderate to severe loss of small neurones in the striatum. ChAT activities in the striatum varied from case to case, in proportion to various degrees of loss of large neurones in the striatum. These neurotransmitter abnormalities in Pick's disease were exactly the same as those in Huntington's disease. However, dopamine concentrations were markedly reduced in the striatum in Pick's disease, whereas striatal dopamine in Huntington's disease is reported to be increased. A dopamine reduction in the striatum of Pick's disease was more disproportionately prominent than expected for various degrees of nigral cell loss. This may be one of the important factors which prevents the generation of choreic movements in Pick's disease in spite of definite striatal atrophy similar to Huntington's disease.
Url:
DOI: 10.1016/0022-510X(88)90020-2
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GABA and substance P levels in the substantia nigra and the globus pallidus were generally decreased, corresponding to the moderate to severe loss of small neurones in the striatum. ChAT activities in the striatum varied from case to case, in proportion to various degrees of loss of large neurones in the striatum. These neurotransmitter abnormalities in Pick's disease were exactly the same as those in Huntington's disease. However, dopamine concentrations were markedly reduced in the striatum in Pick's disease, whereas striatal dopamine in Huntington's disease is reported to be increased. A dopamine reduction in the striatum of Pick's disease was more disproportionately prominent than expected for various degrees of nigral cell loss. This may be one of the important factors which prevents the generation of choreic movements in Pick's disease in spite of definite striatal atrophy similar to Huntington's disease.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hori, Akira" sort="Hori, Akira" uniqKey="Hori A" first="Akira" last="Hori">Akira Hori</name><name sortKey="Kanazawa, Ichiro" sort="Kanazawa, Ichiro" uniqKey="Kanazawa I" first="Ichiro" last="Kanazawa">Ichiro Kanazawa</name><name sortKey="Kwak, Shin" sort="Kwak, Shin" uniqKey="Kwak S" first="Shin" last="Kwak">Shin Kwak</name><name sortKey="Mizutani, Toshio" sort="Mizutani, Toshio" uniqKey="Mizutani T" first="Toshio" last="Mizutani">Toshio Mizutani</name><name sortKey="Muramoto, Osamu" sort="Muramoto, Osamu" uniqKey="Muramoto O" first="Osamu" last="Muramoto">Osamu Muramoto</name><name sortKey="Nukina, Nobuyuki" sort="Nukina, Nobuyuki" uniqKey="Nukina N" first="Nobuyuki" last="Nukina">Nobuyuki Nukina</name><name sortKey="Sasaki, Hidenao" sort="Sasaki, Hidenao" uniqKey="Sasaki H" first="Hidenao" last="Sasaki">Hidenao Sasaki</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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